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<p><i></i></p></div></div></div></div></header></div></body></html>";s:4:"text";s:37468:"From the Department of Dermatology, Combined Military Hospital, Dhaka, Bangladesh. Safety and efficacy of the 2% cream and 2% shampoo have not been established in patients younger than 18 years. Comments: Background: This dosage often has to be repeated … Children—Use and dose must be determined by your doctor. -When using the foam or gel: Read the US FDA-approved patient labeling (Patient Information); wash hands after use; avoid fire, flame, and/or smoking during and immediately after use B. M. JABUL. -Cream: In the treatment of tinea (pityriasis) versicolor due to Malassezia furfur (Pityrosporum orbiculare)          Diagnosis of TV was made clinically by direct KOH preparation and Wood's lamp examination. -The foam and the gel are indicated for use in immunocompetent patients. 			NIH To treat cutaneous candidiasis, tinea corporis, tinea cruris, tinea pedis, and tinea (pityriasis) versicolor the recommended dose of ketoconazole cream, 2% is to apply once daily to … Rad F, Aala F, Reshadmanesh N, Yaghmaie R. Indian J Dermatol. 2018 Nov;25(1):78-90. doi: 10.1080/10717544.2017.1413444. -Patients should be reevaluated and the diagnosis reconsidered if no improvement is noted after completion of the treatment period. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. -Foam: Store at 20C to 25C (68F to 77F); do not refrigerate; do not expose containers to heat, store above 49C (120F), or store in direct sunlight. By mouth. Ketoconazole cream is used to treat tinea corporis (ringworm; fungal skin infection that causes a red scaly rash on different parts of the body), tinea cruris (jock itch; fungal infection of the skin in the groin or buttocks), tinea pedis (athlete's foot; fungal infection of the skin on the feet and between the toes), tinea versicolor … So what might you be prescribed to treat tinea versicolor? Please read them carefully. Do not breast feed infants while taking this drug … NIZORAL® (ketoconazole) 2% Shampoo is indicated for the treatment of tinea (pityriasis) versicolor caused by or presumed to be caused by Pityrosporum orbiculare (also known as … Köse O, Bülent Taştan H, Riza Gür A, Kurumlu Z. J Dermatolog Treat. Tinea versicolor. 2007 Jul;50(4):311-3. doi: 10.1111/j.1439-0507.2007.01361.x. However, topical antifungals are difficult to apply to a large body surface area and for this reason TV is perhaps more easily treated with systemic agents. The usual duration of treatment is: tinea versicolor 2-3 weeks, tinea corporis 3-4 weeks. Conclusions: Usual Adult Dose for Tinea … NLM All doses are given in 2 or 3 divided doses. Cream: Apply qDay for 2 weeks (6 weeks for tinea … Nail infections are treated for up to twelve months. -The shampoo should not be used on a broken or inflamed scalp. Int J Dermatol 1995; 347: 498–9. Max: 1,200 mg daily. The patients were randomly divided in two groups: group 1 received two 150 mg capsules of fluconazole in a single dose repeated weekly for 2 weeks; and group 2 received two 200 mg tablets of ketoconazole in a single dose repeated weekly for 2 weeks. Adult: Initially, 400-600 mg daily, may be increased by 200 mg daily increments every 7-28 days if tolerated, according to patient’s urinary free or plasma cortisol levels.Maintenance dose range: 600-800 mg daily. Burkhart CG. Tinea versicolor: treatment and prophylaxis with monthly administration of ketoconazole. Ketoconazole cream, 2% is indicated for the topical treatment of tinea corporis, tinea cruris and tinea pedis caused by Trichophyton rubrum, T. mentagrophytes and Epidermophyton floccosum; in the treatment of tinea (pityriasis) versicolor caused by Malassezia furfur (Pityrosporum orbiculare); in the treatment of cutaneous candidiasis caused by Candida spp. Max: 1,200 mg daily. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.        2008;53(3):115-8. doi: 10.4103/0019-5154.43209. The sections below will provide you with more specific information and guidelines related to ketoconazole and its correct use. A favorite systemic regimen for tinea versicolor is single-dose (400 mg) ketoconazole, followed by physical activity to promote secretion of the drug onto the skin via sweating. Dose … Fluconazole-loaded solid lipid nanoparticles topical gel for treatment of pityriasis versicolor: formulation and clinical study.          Clotrimazole cream is an antifungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral… Methods: Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others. Oral ketoconazole is often prescribed but usually only for 10 days at a time. Support for the therapeutic effect in tinea versicolor comes from a three-arm, parallel, double-blind, placebo controlled study in patients who had moderately severe tinea (pityriasis) versicolor. Successful response rates in the primary efficacy population for each of both three-day and single-day regimens of ketoconazole … Twenty-two patients with tinea versicolor (pityriasis versicolor) were treated with a single 400 mg dose of ketoconazole and evaluated one month later. Comparison between fluconazole and ketoconazole effectivity in the treatment of pityriasis versicolor. A number of topical anti-fungal treatment regimens have been shown to produce a greater than 70% clinical response rate. Recurrent tinea versicolor is treated with 400 mg monthly. Flutrimazole shampoo 1% versus ketoconazole shampoo 2% in the treatment of pityriasis versicolor. 1. In an attempt to minimise the dosage and reduce cost, a shorter course of 10 days at the dose of 200 mg per day was tried Other brands: Nizoral Topical, Nizoral A-D, Ketodan, Extina, ... +2 more, prednisone, dexamethasone, hydrocortisone topical, nystatin topical, clotrimazole topical, ketoconazole topical, tacrolimus topical, terbinafine topical, terbinafine, Decadron. 2% Foam: Apply to affected area(s) twice a day for 4 weeks. This includes prescribing patients 2% Nizoral (ketoconazole) … Pharmacology. Two hundred milligrams of ketoconazole in a daily oral dose was effective in producing a clinical and mycologie cure: lesions in thirty-three of thirty-four patients on active drug … Comments: For Adult. Children – Use and dose must be determined by your doctor. INDICATIONS. They tend to develop gradually and may join up to form larger patches over time. General. Twenty-two patients with tinea versicolor (pityriasis versicolor) were treated with a single 400 mg dose of ketoconazole and evaluated one month later. Comments: Then use only as needed to keep dandruff … 2, pp. Pityriasis aka Tinea Versicolor. Topical treatments. Specific dosage adjustment recommendations are available for the Colcrys product for patients who have taken ketoconazole in the past 14 days or require concurrent use: for prophylaxis of gout flares, if the original dose is 0.6 mg twice daily, decrease to 0.3 mg once daily or if the original dose is 0.6 mg once daily, decrease to 0.3 mg once every other day; for treatment of gout flares, give 0.6 mg as a single dose, … While oral ketoconazole is contraindicated for the treatment of tinea versicolor, the topical foam may be useful in some patients. Silva H, Gibbs D, Arguedas J. Ketoconazole foam or gel is used to treat seborrheic dermatitis (scaly areas on your skin or scalp). Comments: The “Azole” antifungal creams. Tinea versicolor treatment and prophylaxis with monthly administration of ketoconazole. While oral ketoconazole is contraindicated for the treatment of tinea versicolor, the topical foam may be useful in some patients. Pramiconazole and sertaconazole have also been used in the management of tinea versicolor. BACKGROUND: A number of effective topical therapies are available for the treatment of tinea versicolor (TV). 1997 Jan. 36(1):64-6. .          One hundred and eighty patients with moderate to extensive pityriasis versicolor confirmed by KOH and Wood's lamp examination were randomly assigned to one of the four oral antifungal regimes: Ketoconazole 400 mg single dose (Category I), Ketoconazole 200 mg daily for 10 days (Category II), Fluconazole 400 mg single dose … Administration advice: For cream dosage form: For cutaneous candidiasis, tinea corporis, tinea cruris, tinea pedis, or pityriasis versicolor: Adults—Apply to the affected area of the skin and the surrounding area once a day. Comments: For other infections: Ketoconazole cream should be applied to the affected areas once or twice daily, depending on the severity of the infection. Select one or more newsletters to continue. Pityriasis versicolor, sometimes called tinea versicolor, is a common fungal infection that causes small patches of skin to become scaly and discoloured. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. We comply with the HONcode standard for trustworthy health information -. Symptoms of pityriasis versicolor. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Tinea versicolor or pityriasis versicolor is a common superficial cutaneous fungal infection characterized by pityriasiform desquamation and hypopigmented or hyperpigmented … Comments: ... by pharmacokinetics and clinical studies are one 100 mg capsule daily for 15 days in cases of tinea corporis and tinea cruris and the same dosage for 30 days in cases of tinea pedis and tinea manuum. Sadeque JB(1), Shahidullah M, Shah OR, Kamal M. Author information: (1)Department of Dermatology, Combined Military Hospital, Dhaka, … Clotrimazole 1%, ketoconazole 2%, econazole 1%, and miconazole 2% are examples that work well when used once or twice daily for one to four weeks. Uses: For the topical treatment of tinea corporis and tinea cruris due to Trichophyton rubrum, T mentagrophytes, and Epidermophyton floccosum; in the treatment of cutaneous candidiasis due to Candida species, 2% Cream: Apply to the affected and immediate surrounding area once a day for 6 weeks. [ 49, 50] A review suggested the following … 			 |  Randomized comparative clinical trial of Artemisia sieberi 5% lotion and clotrimazole 1% lotion for the treatment of pityriasis versicolor. Mycoses. -Stop this drug and contact healthcare provider if irritation occurs or the condition worsens. Pityriasis versicolor can be treated by a single or multiple dosage regime of ketoconazole as well as by fluconazole. 			 |  -The shampoo should be applied to completely wet hair, lathered generously, and then rinsed thoroughly; this should be repeated. Search for … Ketoconazole Shampoo, 2% is indicated for the treatment of tinea (pityriasis) versicolor caused by or presumed to be caused by Pityrosporum orbiculare (also known as Malassezia furfur or M. orbiculare). -The shampoo should not be used on a broken or inflamed scalp. Drugs for subcutaneous and mycoses. ketoconazole 2% shampoo is indicated for the treatment and prophylaxis of infections in which the yeast Malassezia (previously called Pityrosporum) is involved, such as pityriasis versicolor (localized), seborrhoeic dermatitis and pityriasis capitis (dandruff). COVID-19 is an emerging, rapidly evolving situation. is a skin fungal infection usually occurs in warm and moist environment. Kose O. Fluconazole versus itraconazole in the treatment of tinea versicolor. Montero-Gei F, Robles ME, Suchil P. Fluconazole vs. itraconazole in the treatment of tinea versicolor. Comparison of single dose 400 mg versus 10-day 200 mg daily dose ketoconazole in the treatment of tinea versicolor. Drug Deliv. [Medline] . Tinea versicolor: treatment and prophylaxis with monthly administration of ketoconazole. Do not alter dose or dose interval and do not stop taking ketoconazole before consulting the physician. Recurrent Tinea Versicolor (Off-label) 400 mg PO monthly. 2015 Mar 12;1(1):13-29. doi: 10.3390/jof1010013. 12 years or older: All patients were found to be clinically cured when … El-Housiny S, Shams Eldeen MA, El-Attar YA, Salem HA, Attia D, Bendas ER, El-Nabarawi MA. Safety and efficacy of the 2% foam, 2% gel, and 1% shampoo have not been established in patients younger than 12 years. Antifungal Treatment for Pityriasis Versicolor. Tinea infections are caused by dermatophytes and are classified by the involved site. Would you like email updates of new search results? Systemic ketoconazole in tinea versicolor: … Prevention and treatment information (HHS). However, this agent carries an associated risk of hepatitis in less than 1 in 10,000 cases and is rarely used orally for dermatophyte infections.       A total of 128 patients with TV, aged 15-55 years, were entered into a randomized, double-blind, clinical trial comparing the efficacy and tolerance of two regimens of oral treatment for TV. Ketoconazole cream is prescribed to treat fungal infections such as ringworm, jock itch, athlete's foot, dandruff, and tinea versicolor. However, topical antifungals are difficult to apply to a large body surface area and for this reason TV is perhaps more easily treated with systemic agents. [Comparative clinical study of a new imidazole molecule (fluconazole) and ketaconazole in the treatment of Candida albicans vulvovaginitis]. NIZORAL® (ketoconazole) 2% Shampoo is indicated for the treatment of tinea (pityriasis) versicolor caused by or presumed to be caused by Pityrosporum orbiculare (also known as Malassezia furfur or M. orbiculare).. The patient then delays showering or rinsing for 10–12 h, and repeats the therapy in 1 week.        Results: 2% Foam: Apply to affected area(s) twice a day for 4 weeks. Int J Dermatol 1999; 388: 601–3. The oral dose range is 200-400 mg daily. Systemic ketoconazole in the treatment of tinea versicolor. Int J Dermatol. 13, No. Journal of Dermatological Treatment: Vol. Itraconazole in tinea versicolor: A review 1. 2% Shampoo: Apply to damp skin of the affected area and a wide margin surrounding this area, lather, leave in place for 5 minutes, and then rinse off with water. Dosage Forms & Strengths cream/gel/foam. 2% Gel: Apply to affected area once a day for 2 weeks. Oral Ketoconazole--a new treatment for Tinea Versicolor. -The shampoo should be applied to completely wet hair, lathered generously, and then rinsed thoroughly; this should be repeated. Ketoconazole 2% shampoo is used to treat "sun fungus" (tinea versicolor; pityriasis versicolor). Therapeutic Class. Indicated for the treatment of the following systemic fungal infections in patients who have failed or who are intolerant to other therapies: blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis. This medicine may also be used for other fungus infections of the skin as determined by your doctor. -Foam: Holding container upright, dispense an amount sufficient to cover affected area(s) into the cap of the can or onto another cool surface; do not dispense directly onto hands (foam will immediately melt upon contact with warm skin); use fingertips to pick up small amounts of foam and massage into affected area(s) gently until foam disappears; if hair-bearing area, part hair and apply directly to skin (not on hair). Ketoconazole for Pityriasis aka Tinea Versicolor and Dandruff aka Seborrhoeic Dermatitis. 73-76. Clotrimazole 1%, ketoconazole 2%, econazole 1%, and miconazole 2% … 2002 Jun;13(2):77-9. doi: 10.1080/095466302317584430. Children younger than 2 years of age—Use and dose must be determined by your doctor. So what might you be prescribed to treat tinea versicolor? -Only use topically/externally; avoid contact with the eyes, nostrils, mouth, and vagina. Giam YC, Rajan VS. PMID: 6091278 [PubMed - indexed for MEDLINE] Tinea versicolor is a long-term (chronic) fungal infection of the skin. The dose in children is usually 50 mg per day for those weighing less than 20 … Cutaneous candidiasis, tinea corporis, tinea cruris, tinea pedis, and tinea (pityriasis) versicolor: It is recommended that ketoconazole cream, 2% be applied once daily to cover the affected and immediate surrounding area. Cutis 1984;34:470-1. 1% Shampoo: Use topically every 3 or 4 days for up to 8 weeks and then only as needed to control dandruff. 			HHS                  The trial was carried out to determine (i) whether the single dose regimen may be effective in tropical conditions such as exist in the Phil … Comparison of single dose 400 mg versus 10-day 200 mg daily dose ketoconazole … This site needs JavaScript to work properly. Storage requirements: -When using the foam: If product gets in the eyes, mouth, or vagina, rinse areas well with water; do not puncture and/or incinerate container. These medications prevent growth of several types of fungi by preventing production of the membranes that surround fungal cells. Other topical antifungal agents such as clotrimazole, miconazole or … Rigopoulos D, Gregoriou S, Kontochristopoulos G, Ifantides A, Katsambas A. Mycoses. SYSTEMIC KETOCONAZOLE IN THE TREATMENT OF TINEA VERSICOLOR. Uses: To control flaking, scaling, and itching associated with dandruff. The oral dose of ketoconazole in adults is 200 to 400 mg daily, taken for two to eight weeks (a single dose may be effective for pityriasis versicolor). Topical treatments. For seborrheic dermatitis:       Of 128 patients, 100 completed the study and no major side-effects were noted between the two treatment regimens. Available for Android and iOS devices. Ketoconazole, an imidazole, has been used for years both orally and top­ ically with great success, although it has not been approved by the Food and Drug Administration for the indication of tinea versicolor. The over-the-counter shampoo version of ketoconazole can also be used as a body wash for the treatment of tinea versicolor. Singapore Med J. Children—Use and dose … Apply once daily to cover affected and immediate surrounding area for 2 weeks; Tinea Corporis, Tinea Cruris, Tinea Pedis. Ketoconazole 2% cream. Topical formulations are administered to … May result in longer, sustained resolution; Second line: Systemic Antifungal. Ketoconazole cream and clotrimazole are antifungal medications prescribed to treat fungal infections such as jock itch, athlete's foot, ringworm, and tinea versicolor. Cutaneous candidiasis, tinea corporis, tinea cruris, tinea pedis, and tinea (pityriasis) versicolor: It is recommended that ketoconazole cream, 2% be applied once daily to cover the affected and … Ketoconazole may be taken with or without food. Please enable it to take advantage of the complete set of features! National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error.       Fluconazole and ketoconazole demonstrated similar efficacy in the treatment of TV. -Gel: Store at 25C (77F); excursions permitted to 15C to 30C (59F to 86F). Uses: 			USA.gov. 200mg; Fungal Infections. The dose is usually 3.3 to 6.6 milligrams (mg) per kilogram (kg) of body weight per day. 2018 Aug 20;4(3):99. doi: 10.3390/jof4030099. -If an allergic reaction (e.g., generalized rash, skin reactions, severe swelling, dyspnea) develops, stop this drug and consult physician at once. 1997 Jan. 36(1):64-6. Apply once daily to cover affected and immediate surrounding area for 2 weeks; Tinea Corporis, Tinea Cruris, Tinea Pedis. Patient advice: 1984 Jun;25(3):157-60. Consult WARNINGS section for additional precautions. Itraconazole is usually given at 200 mg/d for 7 days. -May see clinical improvement fairly soon after start of therapy; duration of 2 weeks recommended to reduce possibility of recurrence. The … Clipboard, Search History, and several other advanced features are temporarily unavailable. Mazziotti F, Cirillo L, Arena V, Cipriani P, Ghezzi C, Bresadola M, Ragni N, Donadio C, Pellizzari G. J Fungi (Basel). Use: For the topical treatment of tinea pedis due to T rubrum, T mentagrophytes, and E floccosum, 2% Cream: Apply to the affected and immediate surrounding area once a day for 2 weeks. A 4-week, double-blind comparison of ketoconazole and placebo was conducted in sixty-six patients with tinea versicolor. General: Brand Name(s): Nizoral CAS nº: 65277-42-1 (kee-toe-koe-na-zole) Product Info. FDA Information. Ketoconazole 1% shampoo is used to treat dandruff. Adult: Initially, 400-600 mg daily, may be increased by 200 mg daily increments every 7-28 days if tolerated, according to patient’s urinary free or plasma cortisol levels.Maintenance dose range: 600-800 mg daily. Fluconazole versus ketoconazole in the treatment of tinea versicolor. Pityriasis versicolor, sometimes called tinea versicolor, is a common fungal infection that causes small patches of skin to become scaly and discoloured. -Shampoo: For the treatment of tinea (pityriasis) versicolor due to or presumed due to P orbiculare (M furfur). 12 years or older: Side effects associated with these triazoles tend to be minor and low in incidence. Tinea Versicolor Shampoo (2%) Apply to affected area of damp skin, lather, wait 5 min and rinse (one application usually sufficient) Cream. Note: Tinea (pityriasis) versicolor may give rise to hyperpigmented or hypopigmented patches on the trunk which may extend to the neck, arms and upper thighs. Rausch LJ, Jacobs PH. Int J Dermatol . Uses: To control flaking, scaling, and itching associated with dandruff. Newer derivatives, such as fluconazole and itraconazole, have recently been introduced. Therapy of Skin, Hair and Nail Fungal Infections. The usual duration of treatment is: tinea versicolor 2-3 weeks, tinea … Apply once daily for 14 days; Terbinafine (Lamasil) topically. -A single application of the shampoo should be sufficient and then intermittently as needed. The “Azole” antifungal creams. -Cream: Store at 20C to 25C (68F to 77F). The maximal cure rate was achieved at 8 weeks from the start of treatment and decreased slightly afterwards. All doses are given in 2 or 3 divided doses. A randomised double-blind comparative trial. Delescluse, MD Brussels, Belgium Itraconazole, a new orally active triazole antifungal, has been tested in patients with pityiasis versicolor. For cream dosage form: For cutaneous candidiasis, tinea corporis, tinea cruris, tinea pedis, or pityriasis versicolor: Adults—Apply to the affected area of the skin and the surrounding area once a day. J Fungi (Basel). 2007 May;50(3):193-5. doi: 10.1111/j.1439-0507.2006.01352.x. The treatment should be continued until a few days after the disappearance of all signs and symptoms. For 1% shampoo dosage form: For dandruff: Adults – Use every 3 or 4 days for up to 8 weeks. Symptoms of pityriasis versicolor.        Topical antifungal medications are the treatment of choice for tinea versicolor. Patches of skin may be darker or lighter than your normal skin colour, or may be red, brown or pink. The oral dose of ketoconazole in adults is 200 to 400 mg daily, taken for two to eight weeks (a single dose may be effective for pityriasis versicolor). Exercise to sweating after each dose. -The foam and the gel are indicated for use in immunocompetent patients. Background: Tinea versicolor is a superficial fungal infection caused by normal skin flora and treatable by topical and oral anti-fungal medications Objective: To evaluate the clinical and paraclinical response and to compare possible side-effects of a single oral dose of fluconazole and ketoconazole in the treatment of tinea versicolor Dosage Forms & Strengths tablet . Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Ketoconazole, an oral imidazole, discovered in 1980 (1), is an effi- cient drug for persistent localised Tinea versicolor, and extensive Tines versicolor, giving a result of 93% cure (2) with a 30 day regime. 2% Cream: Apply to affected area twice a day for 4 weeks or until clinical clearing. The therapeutic efficacy of these two drugs has not been compared. We also demonstrated a lack of correlation between mycological cure and hypopigmentation at the end of treatment (2 weeks) and the usefulness of Wood's lamp examination in detecting cure of TV. Treatments for tinea versicolor include: Topical antifungal medications - containing either 2.5% selenium sulfide (Selsun shampoo in UK, but not Selsun Blue which contains only 1%) or 2% ketoconazole (Nizoral ointment and shampoo) applied to dry skin and washed off after 10 minutes, repeated daily for 2 weeks. Comparison of a single 400 mg dose versus a 7-day 200 mg daily dose of itraconazole in the treatment of tinea versicolor. After an average of two weeks, 84% of people have been cured. (2002). 1% Shampoo: Use topically every 3 or 4 days for up to 8 weeks and then only as needed to control dandruff. Last updated on March 17, 2020. Notify physician if skin condition fails to respond to topical therapy or worsens or if signs of irritation or sensitivity occur. Cream: Apply qDay for 2 weeks (6 weeks for tinea pedis), covering affected area. [] The risk of serious liver damage, adrenal gland problems, and harmful drug interactions with use of oral ketoconazole outweighs it benefit for fungal skin infections. Uses: For the topical treatment of tinea corporis and tinea cruris due to Trichophyton rubrum, T mentagrophytes, and Epidermophyton floccosum; in the treatment of cutaneous candidiasis due to Candida species. Medically reviewed by Drugs.com. Patches of skin … Applies to the following strengths: 1%; 2%; 2% with cleanser, 2% Cream: Apply to the affected and immediate surrounding area once a day for 2 weeks. -Shampoo: 1%: Store between 2C and 30C (35F and 86F), protect from light and freezing; 2%: Store at 20C to 25C (68F to 77F), protect from light. The treatment should be continued until a few days after the disappearance of all signs and symptoms. The patients were randomly divided in two groups: group 1 received two 150 mg capsules of fluconazole in a single dose repeated weekly for 2 weeks; and group 2 received two 200 mg tablets of … For other infections: Ketoconazole cream should be applied to the affected areas once or twice daily, depending on the severity of the infection. Tinea Versicolor Shampoo (2%) Apply to affected area of damp skin, lather, wait 5 min and rinse (one application usually sufficient) Cream. Comparison of single dose 400 mg versus 10-day 200 mg daily dose ketoconazole in the treatment of tinea versicolor. -When using the 1% shampoo: If product gets into the eyes, rinse thoroughly with water; if condition worsens or does not improve in 2 to 4 weeks or if rash develops, stop using this product and consult physician. Results of the study showed no significant differences in efficacy, safety and tolerability between the two treatment regimens.       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